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KMID : 0606120140200030225
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Korean Journal of Child Health Nursing
2014 Volume.20 No. 3 p.225 ~ p.235
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Systematic Review of Effects of Nasal Continuous Positive Airway Pressure on Apnea of Preterm Infants
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Kim Eun-Joo
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Abstract
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Purpose: The purpose of this study was to analysis the effects of nasal Continuous Postive Airway Pressure (nCPAP) for preterm infants using systematic review and meta-analysis.
Methods: Thirteen peer-reviewed journals including preterm infants and apnea and nCPAP published between 1973 and 2013 were included. Effect size and statistics of homogeneity were done using STATA 10.0.
Results: The design for 9 studies was Randomized Control Trial. In most of studies the pressure of nCPAP was set to 4-6 cmH2O. The effect size of 5 studies for the effect on apnea rate using nCPAP compared to nasal Intermittent Positive Pressure Ventilator (nIPPV) showed that the Standardized Mean Difference (SMD) was -0.11 and was not significantly different (Z=0.41, p=.680). But the difference in nCPAP for nasal Synchronizes Intermittent Positive Pressure Ventilator (nSIPPV) (subgroup) was significant (SMD=-.44). The effect size of 7 studies on effect for ventilator weaning of using nCPAP compared to nIPPV showed the Risk Ratio (RR) as 1.60 and was not significantly different (Z=1.12, p=.268). But the difference between nCPAP and nSIPPV (subgroup) was significant (RR=3.94).
Conclusion: The results indicate a need for an advanced care system and suggest continuous studies of apnea in preterm infants.
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KEYWORD
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Review, Continuous Positive Airway Pressure, Apnea, Infant, Premature
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